Collagen - Induced Platelet Aggregation With and Without Leukocytes In Patients and Control Subjects
نویسنده
چکیده
Background and Purpose Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Leukocytes can efficiently stimulate as well as inhibit platelet aggregability. We studied the influence of leukocytes on collagen-induced platelet aggregation in patients with acute ischemic stroke. Methods We investigated 23 patients within 2 days after stroke and 23 healthy ageand sex-matched control subjects and determined collagen-induced platelet aggregation in platelet-rich plasma with or without addition of polymorphonuclear or mononuclear leukocytes. Results Platelet aggregation without leukocytes tended to be lower in patients than in control subjects (P=.O6). Mononuclear leukocytes reduced (P=.O18) and polymorphonuclear
منابع مشابه
Acute Ischemic Stroke
Background and Purpose Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Leukocytes can efficiently stimulate as well as inhibit platelet aggregability. We studied the influence of leukocytes on collagen-induced platelet aggregation in patients with acute ischemic stroke. Methods We investigated 23 patients within 2 days after stroke and...
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